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To accommodate this information explosion, MITOMAP has implemented a new relational database and an improved search engine, and all programs have been rewritten. You have entered an invalid code. Sign In or Create an Account. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Consequently, MITOMAP not only provides a valuable reference for the mitochondrial biologist, it may also provide a model for the development of information storage and retrieval systems for other components of the human genome. A clinical database, Mitomed, is also being designed to integrate with these systems. In addition, the mtDNA contains a nt control region that encompasses transcription and replication regulatory elements 2.

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It is reasonable to expect that as the volume and complexity of information increases in other locus-specific databases, they will benefit from similar efforts at integration and expansion. The amount of curated mtDNA data has grown enormously in the past six years since the previous Nucleic Acids Research report. Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy.

Views Read Edit View history. Because of its exposure to ROS, the mtDNA has a very high mutation rate, and new mutations create a mixture of mutant and normal mtDNAs within the cell, called heteroplasmy. This hypothesis has been supported by the recent discovery that somatic mutations in key control-region regulatory elements are elevated in AD brains 6.

MITOMAP: A Human Mitochondrial Genome Database | Nucleic Acids Research | Oxford Academic

Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma. Add comment Close comment form modal. Reproduced with permission of the American Society for Human Genetics.

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MITOMAP -- a human mitochondrial genome database

However, in the intervening years, an assortment of Mutomap with mature data-modeling capabilities have become available which combine aspects of both relational and object-oriented modeling. Finally, mtDNA coding region and control-region mutations are being mltomap in a wide spectrum of cancers 7. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. National Center for Biotechnology InformationU. A data file of the diagnostic nucleotide sequence variants that define the various population-specific mtDNA haplogroups is also maintained, as is a complete list of all known sequence polymorphisms.

MitoMap - Wikipedia

This has resulted in a wide variety of pathologic mutations and neutral polymorphisms. This article is an orphanas no other articles link to it. The mtDNA is a closed circular molecule of 16 nt.

Today, these same variants are known to affect human longevity and predisposition to neurodegenerative diseases such as Alzheimer's disease AD and Parkinson's disease PD 3.

It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Receive exclusive offers and updates from Oxford Academic.

The functional genetic element data set provides the genomic location of the known functional domains of the mtDNA, defined by nucleotide position. Latest Most Read Most Cited Ash2l interacts mltomap Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network. Learn how and when to remove these template messages.

Your comment will be reviewed and published at the journal's discretion. Indeed, different tissues preferentially accumulate specific control region mutations, suggesting that these mutations may affect important regulatory elements 45.

MITOMAP: a human mitochondrial genome database.

Please review our privacy policy. Thank you for submitting a comment on this article. You have entered an invalid code. Miotmap topic of this article may not meet Wikipedia's notability guidelines for companies and organizations. New data extracted by the curator is initially stored, formatted and screened in Excel spreadsheets.

You must accept the terms and conditions. While MITOMAP is a browsable collection of information managed by a curator, Mitomaster is designed to use this information for the analysis of new information submitted by researchers. Author information Copyright and License information Disclaimer.

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